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After two control cycles, 13 normally menstruating women were treated from day 5 to 25 of the third consecutive cycle with nomegestrol acetate (NOM Ac) 1.25, 2.5 or 5 mg once a day. Plasma oestradiol, FSH and LH concentrations were assayed daily from day 5 to day 25 and plasma progesterone concentrations from day 12 to day 25. Ovulation was inhibited in(More)
17 alpha-Acetoxy-6-methyl-19-nor-4,6-pregna-diene-3,20-dione (TX 066) has the pharmacological profile of a pure progestogen with no side effect such as androgenic activity. Its pituitary suppressing effect is relatively weak, as is also its antiestrogenic activity. It possesses a powerful antiandrogenic effect, which, in addition to the classic uses for(More)
Gonadotrophins influence in ovarian portal graft growth is studied. Grafts are made or in immature female rats and let to growth for one month, either in adult female rats and let to growth for six months. FSH and LH production is stopped with methallibure. In the two cases the graft, tumourous or not, is under the gonadotrophins dependancy, but others,(More)
19-Norprogesterone (19-NOR-P) is a potent progestagen in mammals by s.c. injection, but is almost inactive when given p.o. In the rat, 19-NOR-P also shows marked salt-retaining and hypertensive effects, consistent with its high affinity for mineralocorticoid receptors (MR). We synthetized recently some p.o. active 19-NOR-P derivatives, and have examined the(More)
Immature female rabbits were tested by the Clauberg-MacPhail technique using progesterone (P), or nomegestrol acetate (NOM), a 19-norprogesterone derivative. The endometrial surface was observed by scanning electron microscopy. Estrogen priming followed by treatment with P induced changes on the endometrial surface which were very close to those observed in(More)