The modulation of host cell apoptosis by bacterial pathogens is of critical importance for the outcome of the infection process. The capacity of Bartonella henselae and B. quintana to cause vascular tumor formation in immunocompromised patients is linked to the inhibition of vascular endothelial cell (EC) apoptosis. Here, we show that translocation of BepA,… (More)
Photonic Analog-to-Digital Conversion (ADC) has a long history. The premise is that the superior noise performance of femtosecond lasers working at optical frequencies enables us to overcome the bottleneck set by jitter and bandwidth of electronic systems and components. We discuss and demonstrate strategies and devices that enable the implementation of… (More)
A key device in future high speed short reach interconnect technology will be the optical modulator. These devices, in silicon, have experienced dramatic improvements over the last 6 years and the modulation bandwidth has increased from a few tens of MHz to over 30 GHz. However, the demands of optical interconnects are significant. Here we describe an… (More)
Advances in femtosecond lasers and laser stabilization have led to the development of sources of ultrafast optical pulse trains that show jitter on the level of a few femtoseconds over tens of milliseconds and over seconds if referenced to atomic frequency standards. These low jitter sources can be used to perform opto-electronic analog to digital… (More)
We propose and demonstrate a scalable high-sensitivity approach for achieving multi-rate DPSK using a single transmitter and fixed-interferometer-receiver design. Near-theoretical real-time performance is demonstrated over static and fading channels at rates from 2.4Mbps to 2.5Gbps.
A Mach-Zehnder based silicon optical modulator has been demonstrated with a bandwidth of 26 GHz and a VπL of 2 V·cm. The design of this modulator does not require an epitaxial overgrowth.