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In Austria, registration of malignant brain tumours is legally mandatory, whereas benign and borderline tumours are not reported. The Austrian Brain Tumour Registry (ABTR) was initiated under the auspices of the Austrian Society of Neuropathology for the registration of malignant and non-malignant brain tumours. All Austrian neuropathology units involved in(More)
GRUNDLAGEN: Angabe der Biopsielokalisation (Ösophagus vs. Magen) ist notwendig, um die histologische Diagnose von Reflux-assoziierten Veränderungen am Übergang Ösophagus/Magen zu erstellen. Wir haben den Wert der Videoendoskopie für die Diagnostik am ösophagogastralen Übergang untersucht. METHODIK: 29 konsekutive Patienten (m:w = 17:12) mit(More)
HINTERGRUND: Es herrscht Uneinigkeit darüber, ob ein endoskopisch normal erscheinender gastroösophagealer Übergang bei Patienten mit gastroösophagealer Refluxkrankheit biopsiert werden soll. Wir beschäftigten uns mit dieser Frage und setzten Videoendoskopie und Histopatholgie ein. METHODEN: Bei 114 aufeinander folgenden Patienten (58 männliche) mit(More)
BACKGROUND In early estrogen receptor (ER)-positive/HER2-negative breast cancer, the decision to administer chemotherapy is largely based on prognostic criteria. The combined molecular/clinical EndoPredict test (EPclin) has been validated to accurately assess prognosis in this population. In this study, the clinical relevance of EPclin in relation to(More)
BACKGROUND ER+/HER2- breast cancers have a proclivity for late recurrence. A personalised estimate of relapse risk after 5 years of endocrine treatment can improve patient selection for extended hormonal therapy. METHODS A total of 1702 postmenopausal ER+/HER2- breast cancer patients from two adjuvant phase III trials (ABCSG6, ABCSG8) treated with 5 years(More)
BACKGROUND & AIMS Protein kinase C (PKC) has been implicated as a mediator of growth control during colorectal carcinogenesis, but the mechanisms involved are still a matter of dispute. The aim of this study was to analyze PKC patterns and tissue distribution to gain further insight in PKC function during tumor development in the gut. METHODS PKC(More)
Intraductal papillary-mucinous neoplasms (IPMNs) account for approximately 15% of cystic pancreatic neoplasms and 1–3% of all pancreatic tumors [2, 4, 7]. Depending on the degree of epithelial dysplasia this entity is subdivided into benign, borderline, and malignant noninvasive or invasive tumors [7]. Hence, according to the current World Health(More)
HINTERGRUND: In der Endoskopie beginnt der Magen mit den sogenannten gastralen Schleimhautfalten. Anatomische Studien lassen jedoch vermuten, dass diese Falten zum Ösophagus gehören. Deshalb hat diese Studie die Histologie des Beginns der endoskopisch sichtbaren Magenfalten bei Patienten mit gastroösophagealer Refluxkrankheit untersucht. METHODIK: Bei 35(More)
Atypical meningioma has been introduced as tumour subtype of intermediate biological behaviour between classical and malignant meningiomas. To substantiate this three-step scale of malignancy, we assessed the proliferative activity reflected by Ki-67 (MIB1) labelling index (LI) in a series of 89 meningiomas, including 15 classical, 29 atypical, 35(More)
Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and in uterus undergoing apoptosis in vivo show immunostaining(More)