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  • R Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan, Emily A Gaman, Joseph B. Houston, Larry M. Tremaine
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2006 (First Publication: 1 January 2006)
  • The accuracy of in vitro inhibition parameters in scaling to in vivo drug-drug interactions (DDI) was examined for over 40 drugs using seven human P450-selective marker activities in pooled humanExpand
  • Thorir D. Bjornsson, J. Thomas Callaghan, +19 authors Steven A. Wrighton
  • Medicine, Chemistry
  • Drug metabolism and disposition: the biological…
  • 2003 (First Publication: 1 July 2003)
  • Current regulatory guidances do not address specific study designs for in vitro and in vivo drug-drug interaction studies. There is a common desire by regulatory authorities and by industry sponsorsExpand
  • Scott W. Grimm, Heidi J. Einolf, +13 authors R Scott Obach
  • Biology, Medicine
  • Drug Metabolism and Disposition
  • 2009 (First Publication: 1 July 2009)
  • Time-dependent inhibition (TDI) of cytochrome P450 (P450) enzymes caused by new molecular entities (NMEs) is of concern because such compounds can be responsible for clinically relevant drug-drugExpand
  • Angela C. Doran, R Scott Obach, +37 authors Chenghong Zhang
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2005 (First Publication: 1 January 2005)
  • Thirty-two structurally diverse drugs used for the treatment of various conditions of the central nervous system (CNS), along with two active metabolites, and eight non-CNS drugs were measured inExpand