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Colorectal cancer is the second leading cause of cancer death in developed countries. Genome-wide association studies (GWAS) have successfully identified novel susceptibility loci for colorectal cancer. To follow up on these findings, and try to identify novel colorectal cancer susceptibility loci, we present results for GWAS of colorectal cancer (2,906(More)
BACKGROUND Most studies of meat and colorectal adenoma have investigated prevalent events from a single screening, thus limiting our understanding of the role of meat and meat-related exposures in early colorectal carcinogenesis. METHODS Among participants in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial who(More)
Although convergence to stability is typically a complex and irregular process, the Kullback distance provides a measure that moves consistently to 0 as a population becomes stable. The roots of the Kullback distance are in information theory, but it is a meaningful demographic quantity. It reflects a population's log momentum, or the amount of growth built(More)
1 Introduction 64 2 Period and cohort life expectancy 64 3 Period and cohort life expectancy age-decomposition 66 4 Changes in period and cohort life expectancy 67 4.1 Period and cohort models of mortality 67 4.2 Trends, gaps and lags involving period and cohort life expectancies 69 4.3 Age-specific contributions to changes in period and cohort life(More)
Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk of colorectal cancer. We tested interactions between these dietary factors and approximately 2.7 million genetic variants for colorectal(More)
Lyme arthritis results from colonization of joints by Borrelia burgdorferi and the ensuing host response. Using gene array-based differential analysis of B. burgdorferi gene expression and quantitative reverse trancription-polymerase chain reaction, we identified two paralogous spirochete genes, bmpA and bmpB, that are preferentially up-regulated in mouse(More)
Genome-wide association studies (GWAS) have successfully identified a number of single-nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk. However, these susceptibility loci known today explain only a small fraction of the genetic risk. Gene-gene interaction (GxG) is considered to be one source of the missing heritability. To(More)