R. Schipper

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Ornithine decarboxylase (ODC) is a key enzyme in polyamine biosynthesis. Increased polyamine levels are required for growth, differentiation, and transformation of cells. In situ detection of ODC in cells and tissues has been performed with biochemical, enzyme cytochemical, immunocytochemical, and in situ hybridization techniques. Different localization(More)
OBJECTIVES This systematic review aimed to assess the role of magnetic resonance imaging (MRI) in evaluating residual disease extent and the ability to detect pathologic complete response (pCR) after neoadjuvant chemotherapy for invasive breast cancer. METHODS PubMed, the Cochrane Library, MEDLINE, and Embase databases were searched for relevant studies(More)
We recently reported that a high amount of ammonia was produced in the culture medium of H35 hepatoma cells in reponse to ionising radiation (Van Rijn et al, 2003). As a result of hyperammonia and the accompanying pH increase, surviving cells failed to develop into colonies at high inoculation densities. The expected clonogenic potential of the cells(More)
A personal computer program (COMPSEQ) has been developed which can present an informative listing of pre-aligned exonic nucleotide sequences and of their translations to amino acid sequences as well run triplet-oriented analyses on these sequences in a given reading frame. The sequence listing focuses on the differences between related sequences by(More)
Radiotherapy to the head and neck area damages the salivary glands. As a consequence hyposalivation may occur, but also the protein composition of saliva may be affected possibly compromising oral health. The aim of our study was to compare the relative abundance of proteins and peptides in parotid saliva of irradiated patients to that of healthy controls.(More)
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