R. S. Kadam

Learn More
Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR agonists have been shown to limit the cellular cholesterol content by inducing reverse cholesterol transport, increasing bile acid production, and inhibiting intestinal cholesterol absorption. Most of them, however, also increase lipogenesis via sterol regulatory(More)
PURPOSE First, to determine the influence of drug lipophilicity (using eight beta-blockers) and molecular weight (using 4 kDa and 40 kDa fluoroscein isothiocyanate [FITC]-dextrans) on suprachoroidal delivery to the posterior segment of the eye by using a rabbit ex vivo eye model. Second, to determine whether drug distribution differs between the dosed and(More)
The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP). There are no effective therapies to treat this condition. Compounds that enhance dissociation of protein aggregates may be of value in(More)
PURPOSE Dendrimeric polyguanidilyated translocators (DPTs) are nanosized novel dendrimers that efficiently translocate molecules across biological barriers. The purpose of this study was to develop a DPT that could serve as an ophthalmic delivery vehicle for gatifloxacin and to evaluate its in vitro and in vivo delivery after topical application. METHODS(More)
PURPOSE To determine the influence of drug lipophilicity, ocular pigmentation, and species differences on transscleral solute transport. METHODS The transport of eight β-blockers across excised sclera/sclera-choroid-RPE (SCRPE) of albino rabbit, pigmented rabbit, human, porcine, and bovine eyes was determined over 6 hours. The ex vivo transscleral(More)
PURPOSE To determine whether exposure of sodium fluorescein (NaF) to the choroid-retina region in the posterior segment of the eye is greater with suprachoroidal injection when compared to intravitreal and transscleral routes. METHODS Suprachoroidal injection, a new approach for drug delivery to the posterior segment of the eye was validated using a 34 G(More)
the LC-MS/MS data in the above article. An investigation by the University of Colorado determined that some LC-MS data in several other papers were falsified or fabricated by Rajendra Kadam, who was the only respondent in the investigation. The Investigation Committee was unable to validate the LC-MS data in the above-referenced publication and thus could(More)
Since there is paucity of information on solute transporters in human ocular tissues, the aim of this study was immunohistochemical and functional characterization of PEPT, OCT, ATB 0,+ , and MCT transporters in human ocular barriers. Immunohistochemical localization of transporters was achieved using 5 µm thick paraffin embedded sections of the whole human(More)