R. Ravindra

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The important anticancer drug paclitaxel binds to the beta-subunit of the alphabeta-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have been proposed. In previous work we presented(More)
To understand the mechanism of ethanol action on G protein-mediated signal transduction pathway, the effect of ethanol on muscarinic receptor-G protein coupling in the rat cerebral cortex was examined. Acetylcholine (ACh)-stimulated G protein GTPase activity was used as an index of receptor-G protein coupling. ACh stimulation of G protein GTPase activity(More)
In lactating rats, suckling stimulated the in-vitro tubulin assembly of cold-labile pituitary tubulin fraction by about 70%. Domperidone and alpha methyl-p-tyrosine stimulated the pituitary tubulin assembly by 90% and 325%, respectively. In another experiment, pituitaries from a group of lactating rats (no reference to suckling) were processed to obtain(More)
A [3H]colchicine-binding assay was employed for estimating the relative amounts of soluble and polymerized tubulin present in an individual anterior pituitary lobe. Colchicine binding to these two tubulin pools was time dependent and dose responsive. Scatchard analysis of the binding revealed that [3H]colchicine bound to both fractions with similar(More)
The work reports validation of numerical weather forecasts (NWF), QuikSCAT-based wind speed and AMSR-E sea surface temperature (SST) for the surface atmospheric boundary layer in the Indian sector of the Southern Ocean under the International Polar Year. The database consists of wind speed, air temperature, relative humidity, sea level pressure collected(More)
  • M E M Landau, L Levanon, M Leiserowitz, J Lahav, D E Hooks, C M Yip +36 others
  • 2005
a lattice that has an in-plane orientational epitaxy with the underlying mica lattice. The only reason x-ray analysis can be carried out on these structures is because we are able to signal average over a large collection of prisms that are aligned with one another and epitaxially arranged on the mica support. This approach to controlling and monitoring the(More)
The mechanism of ethanol inhibition of glucose uptake was investigated using C6 glioma cells. Basal [3H]2-deoxy-D-glucose (2DG) uptake by C6 cells was inhibited by ethanol in a concentration-dependent manner. Fifty, 75 and 100 mM ethanol significantly inhibited basal 2DG uptake by 12, 20 and 23%, respectively (p < 0.05). Carbachol (an agonist acting via G(More)
The role of G proteins in glucose uptake was investigated using C6 glioma cells. Carbachol (an agonist acting via G protein coupled receptors) and 5'-guanylylimidodiphosphate (Gpp(NH)p; a nonhydrolysable guanine nucleotide analog which bypasses the receptors and directly activates G proteins) stimulated [3H]2-deoxy-D-glucose (2DG) uptake by C6 cells,(More)