R. R. Parks

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Free radicals have been implicated in the pathogenesis of an increasing number of diseases and inflammatory states. They may cause tissue damage by their chemical modification of proteins, carbohydrates, nucleotides, and lipids. Lipid peroxidation occurs as a consequence of free radicals acting on the polyunsaturated fatty acids of cellular membranes. To(More)
Cu, Zn superoxide dismutase (SOD) is a metalloprotein that catalyzes the dismutation of the superoxide anion into O2 − and H202, and therefore functions to maintain a low intracellular concentration of an otherwise toxic metabolite of oxygen. SOD protects living tissue from the destructive effects of free radicals. Increasing evidence implicates free(More)
Methods Memory B cells from a chronically infected Tanzanian subject with plasma broad neutralizing activity were labeled with a consensus C envelope (Env) and Env+ cells sorted as single cells. Immunoglobulin heavy and light chain genes were amplified by PCR and analyzed for gene usage and isotype, and then were expressed as recombinant monoclonal(More)
Increasing evidence implicates free radicals in the pathogenesis of inflammatory disease, including otitis media. The anti-oxidant enzymes catalase, glutathione peroxidase and superoxide dismutase protect tissues from the destructive effects of free radicals. Our previous work has shown depressed levels of superoxide dismutase in the infected middle ears of(More)
Recent studies suggest that tumor necrosis factor-alpha (TNF-alpha), a pleiotropic cytokine, is responsible for some of the systemic and local effects, including tumor-associated cachexia and neoplastic bone destruction, seen in patients with cancer. This study was undertaken to determine if TNF-alpha is produced by human squamous cell carcinoma of the head(More)
Background HIV-1 vaccines must induce protective antibodies at mucosal surfaces; the role of IgA in protection remains unknown. The HIV-1 Env antibody response begins ~day 17 after transmission, and derives from a polyreactive memory B cell pool of gut flora-reactive IgG1 and IgA B cells. Whereas the IgG Env antibody response persists years after acute(More)
Open Access Oral presentation S021-04 OA. A large-scale analysis of immunoglobulin sequences derived from plasmablasts/plasma cells in acute HIV-1 infection subjects S Munshaw*1, H Liao1, A Dixon1, X Chen1, A Nagel1, K Derosa1, R Parks1, J Amos1, JF Whitesides1, DJ Marshalls1, Y Yang1, F Gao1, GD Tomaras1, MA Moody1, GH Kelsoe1, TC Shea2, DM Margolis2, M(More)
Antibody lineages with evidence of somatic hypermutation persisting for >4 years in a South African subject with broad neutralizing activity M Moody, AM Trama, M Bonsignori, C Tsao, MS Drinker, TC Gurley, JD Amos, JA Eudailey, LC Armand, R Parks, KE Lloyd, S Wang, K Seo, J Lee, KJ Jackson, R Hoh, T Pham, KM Roskin, SD Boyd, AZ Fire, ES Gray, L Morris, H(More)
Background Successful vaccines (e.g. tetanus) can induce long-lived antibody levels that are maintained by long-lived plasma cells and do not correlate with numbers of blood memory B-cells. Early events during HIV-1 acute infection may impair the timely onset of neutralizing antibody responses. Thus, an effective HIV-1 vaccine should elicit high levels of(More)
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