R R Mosmann

  • Citations Per Year
Learn More
Murine B cells stimulated with lipopolysaccharide (LPS) and interleukin (IL) 4 produce IgG1 and IgE, but synthesize IgG2a when stimulated with LPS and interferon-gamma. The cytokines, however, that regulate immunoglobulin (Ig) synthesis induced in normal B cells under antigen-driven major histocompatibility complex (MHC)-restricted conditions in the absence(More)
Many long-term mouse Th cell clones can be divided into two types, based on the pattern of cytokines secreted in response to antigen or lectin stimulation . Thl clones secrete IL-2, IFN-y, and lymphotoxin (LT),' whereas Th2 clones express IL4, IL-5, IL-6, and a gene of unknown function, P600 (1-4) . Both types of clone secrete IL-3, granulocyte-macrophage(More)
  • 1