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The antigonadotropic activity of cyclic 2,6-cis-diphenylhexamethylcyclotetrasiloxane was investigated in be male rat. The compound was administered orally and the effects were compared with those caused by the subcutaneous administration of estradiol benzoate. The cyclosiloxane lowered serum luteinizing hormone (LH) and follicle stimulating hormone (FSH)(More)
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