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On the basis of measurements on fresh human brains (n = 33), changes in size of the brain stem which occurred as a result of formalin fixation and embedding in paraffin were quantified and converted into linear correction factors. In contrast to the known changes in the cerebrum, the formalin fixation did not result in a 'positive formalin effect', but left(More)
BACKGROUND To the Vypro II mesh, a large-pore-sized multifilamentous polypropylene mesh for hernia repair, supplementary polyglactin 910 multifilaments were added to improve intraoperative handling. As it has been suggested that polyglactin induces fibroplastic reactions and wound complications, this study was designed to evaluate the long-term tissue(More)
OBJECT The development of appropriate methods to stimulate the dorsal and ventral cochlear nucleus by means of an auditory brainstem implant in patients with acquired bilateral anacusis requires a detailed topoanatomical knowledge both of the location and extension of the nuclear surface in the fourth ventricle and lateral recess and of its variability. The(More)
OBJECT The goal of this study was to determine the biocompatibility of polyester mesh electrode carriers for auditory brainstem implants with and without adhesives in a rat model. METHODS Physical properties of the meshes were evaluated within the fourth ventricle region, both without (Group A) and with adhesives (muscle, Group B; oxidized regenerated(More)
The facial nerve is monitored intra-operatively using electromyography to identify and prevent damage during the excision of an acoustic neurinoma. In order to determine whether a profound level of peripheral neuromuscular blockade could be achieved without compromising facial electromyographic monitoring, 11 patients undergoing resection of acoustic(More)
A 51-year-old man is reported who was suffering from an extensive right-sided glossopharyngeal neurinoma (4.6 x 3.4 cm). The patient was admitted with a history of headache for six to seven years and vomiting for two years accompanied by a progressive hearing loss, tinnitus and dizziness during the last year. Audiometry indicated a perceptive deafness in(More)
Advances in neuroscience require better anatomical knowledge of neuronal architecture and structural details. Optimal embedding techniques are the basis for precise morphometric studies in section series as well as for the evaluation of tissue specimens or implants of differing hardness. There are very few methods for preparing large specimens by resin(More)
OBJECTIVES To analyze the biocompatibility of multifilament polyester (PET) meshes used for the implantation of auditory brainstem implants in a standardized Wistar rat model (n=29). METHODS The physical properties of the meshes were examined during surgery. Using a modified plastic embedding, the local tissue reaction and the stability of mesh position(More)
Restitution or improvement of impaired brain function following severe head trauma essentially depends on immediate and systematic application of adequate rehabilitation measures. In an collaborative study of the University of Cologne Rehabilitation Centre and Clinic for Neurosurgery, the question is investigated whether early-onset stimulation therapy(More)
The comprehensive assessment of a frontal lobe injury is one of the most complex problems in diagnosis and treatment due to the variability of nature, extent and effect of various disorders of higher cerebral functions, i. e. impairment of the ability to act systematically, attention, motivation and emotionality. This brings about considerable differences(More)