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In January 2000, Chilean Ministry of Health mandated the addition of folic acid (FA) to wheat flour in order to reduce the risk of neural tube defects (NTDs). This policy resulted in significant increases in serum and red cell folate in women of fertile age 1 year after fortification. To evaluate the effect of wheat flour fortification on the prevalence of(More)
BACKGROUND Mandatory fortification with folic acid (FA) was implemented in Chile in 2000. Thereafter, the rate of spina bifida decreased by 52 to 55%. Genetic abnormalities in folate metabolism may be involved in the etiology of spina bifida. AIM To evaluate the association between myelomeningocele (MM) and c.A1298C and c.C677T polymorphisms within the(More)
OBJECTIVE To assess whether iron and folic acid supplementation reduce the risk of low birthweight (LBW) in women without anaemia. DESIGN Case-control study. SETTING University Hospital of Cantabria. STUDY POPULATION Cases were 322 mothers without anaemia delivering a singleton infant of less than 2500 g. Controls were 934 mothers without anaemia(More)
Congenital deafness is defined as the hearing loss which is present at birth and, consequently, before speech development. It is the most prevalent sensor neural disorder in developed countries, and its incidence is estimated between 1-3 children per 1,000 newborns, of which more than 50% are attributable to genetics causes. Deafness can be classified as(More)
BACKGROUND In Chile, 14 to 16% of births occur in teenage mothers. These mothers apparently have a higher frequency of premature labor, low birth weight and congenital malformations. AIM To assess the frequency of prematurity, congenital malformations and weight at birth among the offspring of adolescent mothers. PATIENTS AND METHODS The births occurred(More)
Obese/diabetic mothers present a higher risk to develop offspring with myelomeningocele (MM), evidence supporting the role of energy homeostasis-related genes in neural tube defects. Using polymerase chain reaction-restriction fragment length polymorphism, we have genotyped SLC2A1, HK1, and LEPR single-nucleotide polymorphisms in 105 Chilean patients with(More)
  • Lappi-Blanco, E Kaarteenaho-Wiik, +10 authors R Pardo
  • 2003
strand breaks in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1996;154:477–483. 12. Lappi-Blanco E, Kaarteenaho-Wiik R, Salo S, Sormunen R, Määttä M, Autio-Harmainen H, Soini Y, Pääkkö P. Laminin-5 2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2004;169:27–33. 13. Selman M, Ruiz V,(More)
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is the most common craniofacial birth defect in humans, the etiology of which can be dependent on the interactions of multiple genes. We previously reported haplotype associations for polymorphic variants of interferon regulatory factor 6 (IRF6), msh homeobox 1 (MSX1), bone morphogenetic protein(More)
In the last decade a lot of attention has been payed to problems with nonlinear boundary conditions. Hence, nowadays the underlying mechanisms for dissipativeness or blow–up of solutions is fairly well understood; see e.g. [7, 4, 6, 18, 19]. Therefore, it is a natural question to analyse the dynamics and bifurcations induced by the nonlinear boundary(More)
Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting results for the association of maternal methylation status biomarkers in the aetiology of the main craniofacial birth defects:(More)