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Six thymomas were studied with monoclonal and polyclonal antisera and an immunohistochemical technique to characterize the lymphocytic and epithelial components of the tumor. The T lymphocytes had characteristics of thymocytes, and cortico medullary differentiation was demonstrated within all tumors, regardless of histologic appearance. Cortical thymocytes(More)
Cyclosporine A (CsA) is a potent immunosuppressive drug that has widespread clinical uses in organ transplantation and the treatment of autoimmune disorders. However, the drug's clinical applications are on an empiric basis with a poor understanding of the basic mechanism(s) of action. CsA may exert some of its effects by binding to a cellular receptor(More)
We examined the effects of generalized seizures on heat shock protein (hsp) mRNA induction in the rat brain using in situ hybridization. Seizures induced by electroconvulsive shock, electrical or cocaine kindling caused a selective induction of the constitutive hsp 73 gene in the dentate gyrus. In these seizure paradigms, not thought to induce widespread(More)
We used specific antibodies in immunoblot studies of membrane fractions derived from bovine retina, and in immunohistochemical studies of sections of rat retina to determine the distribution of two guanine nucleotide binding proteins Go (a G-protein of unknown function discovered in the brain) and transducin, in retina. Both Go and transducin were readily(More)
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