R. P. Kucherenko

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Electron microscopy of rats ultrathin sections from dorsal and central raphe nucleus and spinal cord after 5,7-dihydroxytryptamine intracisternal microinjection (200 micrograms) has revealed neurones and axonal terminals distruction, which associated with tail-flick hypoalgesia and blood pressure nociceptive reactions diminished. In this condition the(More)
Controlled and uncontrolled stimulation of the motor activity of 18-day chick embryo induces ultrastructural changes in sensomotor region of the archistriatum. These changes include the increase in the bulk of membrane structures, the increase of the area of presynaptic regions, the increase in electron density of microtubules and neurofilaments. Formation(More)
Selective neurotoxic effect of 6-hydroxydopamine on the catecholaminergic systems was used to study the structural changes in the locus coeruleus and ventral tegmental neurons. Compared with the earlier published data on the blood-brain barrier permeability, the peculiarities of the responses of a part of neurons and synapses of the sites under study(More)
Electron microscopical investigation of the ventral tegmental area at various time after administration of a specific neurotoxin 6-hydroxydopamine made it possible not only to reveal catecholamine reactive elements, but also those structural reorganizations in them, that are dependent on the lesion of the catecholaminergic systems, including certain changes(More)
Local changes in the pial microcirculationwere thus demonstrated in response to laser irradiation. The vessels of the microcirculatory bed differ in their sensitivity to laser irradiation. The intensity of the reaction depends on the duration of exposure, the diameter of the microvessel, and the animal's age. With age both the degreeiof magnitude of the(More)
Metergoline and 5, 7-dihydroxytryptamine were found to suppress and to prevent an electroanalgesic effect, resp. An increase in the serotonine contents in the CSF after electroanalgesia suggests an activation of the brain serotoninergic system. DL-5-hydroxytryptophan and allopurinol enhanced the electroanalgetic effect. The data obtained suggests an(More)
The selective lesion of the afferent serotoninergic system by means of intracisternal administration of 5,7-dihydroxytryptamine produces certain structural rearrangements in a part of cellular elements and in various parts of the neuropil of the neocortical parietal area. The deficiency of serotoninergic innervation influences the metabolic processes. This(More)