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Proton pump inhibitors were shown to affect the sensitivity of the gastric mucosa to chemical agents. This effect is associated with inhibition of proton back-diffusion and increase in the permeability of the gastric epithelium. We studied the effect of omeprazole on gastric secretion of bicarbonates and pepsinogen induced by irritation of the gastric… (More)
Acute experiments on anesthetized rats showed that group B nerve fibers of the subphrenic portion of the vagus nerve do not participate in the regulation of gastric secretion. Gastric acid production is mainly controlled by fast C-fibers (2.11 0.09 m/sec), while secretion of pepsinogen and bicarbonates depends on activity of both fast and slow (0.95 0.11… (More)