R P Dawber

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We have used sensitive electron-histochemical methods to study the subtle ultrastructural variations of cystine incorporation into the hair shaft in trichothiodystrophy. We have shown a general reduction in the cystine (sulphur) content of both the cuticle and the cortex. Discontinuity, and in some cases, complete absence of the cuticular A-layer results in(More)
Acquired progressive kinking of hair is an entity distinct from woolly hair in its onset at or after puberty, predominant involvement of frontal, temporal, and vertex regions of the scalp as well as the supra-auricular and postauricular margins, and a tendency for affected hairs to resemble pubic hair both in texture and color. We consider the condition to(More)
Certain scalp hair shafts from 2 of 10 cases of pili annulati examined by scanning electron microscopy exhibited an unusual weathering pattern. The majority of affected hair shafts showed minor surface abnormalities at regular intervals (nodes) associated with the underlying spaces. However, in a few examples, there was marked damage to the cuticle at the(More)
Three possible mechanisms of the hair shaft abnormality in cheveux incoiffables have been investigated in nine patients. Cheveux incoiffables hairs were found to exhibit a normal distribution of cystine-rich protein within both the cuticle and the cortex, as determined by silver methenamine ultrastructural cytochemistry. Resistance to stretching, at 65%(More)
Using information from a light microscope integrated with a computer, we quantified the variation in node and internode dimensions in monilethrix. We combined this with rate of growth measurements in individual hairs to make the following conclusions. There is considerable variation of node and internode configuration within single hairs. Hairs from the(More)