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It has been suggested that the quality of clinical trials should be assessed by blinded raters to limit the risk of introducing bias into meta-analyses and systematic reviews, and into the peer-review process. There is very little evidence in the literature to substantiate this. This study describes the development of an instrument to assess the quality of(More)
OBJECTIVE To quantify the antiemetic efficacy and adverse effects of cannabis used for sickness induced by chemotherapy. DESIGN Systematic review. DATA SOURCES Systematic search (Medline, Embase, Cochrane library, bibliographies), any language, to August 2000. STUDIES 30 randomised comparisons of cannabis with placebo or antiemetics from which(More)
BACKGROUND Antiepileptic drugs have been used in pain management since the 1960s. Pregabalin is a recently developed antiepileptic drug also used in management of chronic neuropathic pain conditions. OBJECTIVES To assess analgesic efficacy and associated adverse events of pregabalin in acute and chronic pain. SEARCH STRATEGY We searched MEDLINE, EMBASE,(More)
BACKGROUND This review is an update of a review published in 2011, itself a major update of previous reviews published in 2005 and 2000, investigating the effects of gabapentin in chronic neuropathic pain (pain due to nerve damage). Antiepileptic drugs are used to manage chronic neuropathic pain and fibromyalgia. OBJECTIVES To assess the analgesic(More)
One way to ensure adequate sensitivity for analgesic trials is to test the intervention on patients who have established pain of moderate to severe intensity. The usual criterion is at least moderate pain on a categorical pain intensity scale. When visual analogue scales (VAS) are the only pain measure in trials we need to know what point on a VAS(More)
OBJECTIVE To review the effectiveness and safety of topical non-steroidal anti-inflammatory drugs in acute and chronic pain conditions. DESIGN Quantitative systematic review of randomised controlled trials. DATA SOURCES 86 trials involving 10,160 patients. MAIN OUTCOME MEASURES Measures of treatment success approximating at least 50% reduction in(More)
The objective was to improve understanding of adverse events occurring with celecoxib in the treatment of osteoarthritis and rheumatoid arthritis. Data were extracted from company clinical trial reports of randomised trials of celecoxib in osteoarthritis or rheumatoid arthritis lasting 2 weeks or more. Outcomes were discontinuations (all cause, lack of(More)
OBJECTIVE To establish whether cannabis is an effective and safe treatment option in the management of pain. DESIGN Systematic review of randomised controlled trials. DATA SOURCES Electronic databases Medline, Embase, Oxford Pain Database, and Cochrane Library; references from identified papers; hand searches. STUDY SELECTION Trials of cannabis given(More)
This paper reports the trial of a wearable data capture device, SenseCam, as a resource for digital narratives and uses data from the trial to reflect on the models of the 'mind' that underscore HCI. More particularly, over a period of one week, 5 participants and 2 researchers used SenseCams to capture digital traces of their experiences, and used the same(More)
BACKGROUND Anticonvulsant drugs have been used in the management of pain since the 1960s. The clinical impression is that they are useful for chronic neuropathic pain, especially when the pain is lancinating or burning. OBJECTIVES To evaluate the analgesic effectiveness and adverse effects of gabapentin for pain management in clinical practice. SEARCH(More)