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We describe DPOCL, a partinl-order csnsal llnk planner that includes action decomposition. DPOCL builds directly on the SNLP algorithm (McAllester Rosenbiltt 1991), and hence is clear and simple, ud can readily be integrated with other SNLP extensions. In addition, DPOCL is specifically designed to handle partially specified action decompositions. Plan(More)
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this malignancy despite recent advances in therapy. Constitutive nuclear factor (NF)-κB and JAK kinase signalling promotes malignant cell survival in these lymphomas, but the genetic basis for this signalling is incompletely understood. Here we(More)
A role for B-cell-receptor (BCR) signalling in lymphomagenesis has been inferred by studying immunoglobulin genes in human lymphomas and by engineering mouse models, but genetic and functional evidence for its oncogenic role in human lymphomas is needed. Here we describe a form of 'chronic active' BCR signalling that is required for cell survival in the(More)
Burkitt's lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL in developing countries, necessitating new strategies. The normal germinal centre B cell is the presumed cell of origin for both BL and diffuse large B-cell lymphoma (DLBCL), yet gene(More)
Current 3D game engines offer the potential for new types of interactive storytelling. In this paper, we discuss automated cinematography as it relates to interactive narratives in virtual worlds. Due to the interactive nature of these environments, automated camera controllers cannot fully utilize all of the idioms in the domain of cinematography. It is(More)
Intelligent systems are often called upon to form plans that direct their own or other agents' activities. For these systems, the ability to describe plans to people in natural ways is an essential aspect of their interface. In this paper, I present the Cooperative Plan Identiication CPI architecture, a computational model that generates concise, eeective(More)
Respiratory infections, including Mycoplasma pneumoniae (Mp), contribute to asthma pathobiology. To date, the mechanisms underlying the increased susceptibility of asthmatics to airway Mp infection remain unclear. Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is a recently described large airway epithelial cell-derived molecule that was(More)
This paper describes a foundation for an interface to allow non-technical human authors to collaborate with an automated planning system to design interactive narrative. Drawing from research in advisable and mixed-initiative planning, a domain metatheory is presented that allows for qualitative elaborations of narrative domains. The authors describe a(More)
In interactive plan-based narrative environments, users' actions must be monitored to ensure that conditions necessary for the execution of narrative plans are not compromised. In the Zocalo system, management of user actions has been performed on a reactionary basis by a process called mediation. In this paper, we describe an extension to this approach,(More)