R. Michael Porter

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BACKGROUND Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier deficiency initiating AD came from flaky tail mice, which have a frameshift mutation in Flg and also carry an unknown gene, matted, causing a(More)
We study conformal mappings from the unit disk to circular-arc quadrilat-erals with four right angles. The problem is reduced to a Sturm-Liouville boundary value problem on a real interval, with a nonlinear boundary condition, in which the coefficient functions contain the accessory parameters t, λ of the mapping problem. The parameter λ is designed in such(More)
Psoriasis is an incurable autoimmune disease characterized by patches of abnormal red, itchy and scaly skin. This work examined the modulation of inflammation, hyperproliferation and immune cell markers following topical application of fish oil (FO) in comparison to the antipsoriatic agents, betamethasone dipropionate (BD) and salicylic acid (SA), to(More)
An effective algorithm is presented for solving the Beltrami equation ∂f = µ ∂f in a planar disk. The algorithm involves no evaluation of singular integrals. The strategy , working in concentric rings, is to construct a piecewise linear µ-conformal mapping and then correct the image using a known algorithm for conformal mappings. Numerical examples are(More)
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