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The solute carrier transmembrane protein prestin (SLC26A5) drives an active electromechanical transduction process in cochlear outer hair cells that increases hearing sensitivity and frequency discrimination in mammals. A large intramembraneous charge movement, the nonlinear capacitance (NLC), is the electrical signature of prestin function. The(More)
PURPOSE This study investigates the performance of a cardiac-based seizure detection algorithm (CBSDA) that automatically triggers VNS (NCT01325623). METHODS Thirty-one patients with drug resistant epilepsy were evaluated in an epilepsy monitoring unit (EMU) to assess algorithm performance and near-term clinical benefit. Long-term efficacy and safety were(More)
One hundred thirty-eight subjects participated in a study on mobile appointment scheduling. Subjects completed a questionnaire on their primary method of managing appointments when away from their desks. Immediately afterwards, subjects completed a session of scheduling four appointments with the interviewer. The most common scheduling systems, in order of(More)
A major challenge to studying Fe-S cluster biosynthesis in higher eukaryotes is the lack of simple tools for imaging metallocluster binding to proteins. We describe the first fluorescent approach for in vivo detection of 2Fe2S clusters that is based upon the complementation of Venus fluorescent protein fragments via human glutaredoxin 2 (GRX2) coordination(More)
Julesz has shown that cross-correlations between two patterns that appear random to either eye alone can give rise to the perception of form and depth when viewed stereoscopically. We produced auditory analogs by presenting eight simultaneous and continuous sine waves to both ears and by either phaseshifting or frequency-shifting one of them relative to its(More)
Inspired by the Defense Advanced Research Projects Agency's (DARPA) recent successes in speech recognition, we introduce a new task for sign language recognition research: a mobile one-way American Sign Language translator. We argue that such a device should be feasible in the next few years, may provide immediate practical benefits for the Deaf community,(More)
The head bobber transgenic mouse line, produced by pronuclear integration, exhibits repetitive head tilting, circling behavior, and severe hearing loss. Transmitted as an autosomal recessive trait, the homozygote has vestibular and cochlea inner ear defects. The space between the semicircular canals is enclosed within the otic capsule creating a vacuous(More)
Prestin, a multipass transmembrane protein whose N- and C-termini are localized to the cytoplasm, must be trafficked to the plasma membrane to fulfill its cellular function as a molecular motor. One challenge in studying prestin sequence-function relationships within living cells is separating the effects of amino acid substitutions on prestin trafficking,(More)
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