R M Van Cauwenberge

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To study the effect of the flavonoid (+)-catechin on cell-matrix interactions two cell types with a different morphology on and adhesion to laminin were used. MO4 virally transformed fetal mouse cells adhere and spread when cultured on top of laminin-coated coverslips or on human amnion basement membrane. M5076 mouse reticulum cell sarcoma cells poorly(More)
Inhibition of the invasiveness of MO4 mouse fibrosarcoma cells by the vinca alkaloid, vinblastine (VLB), vincristine (VCR) and vindesine (VDS), has been examined in vitro. At doses between 0.006 microgram/ml (minimal effect) and 0.1 microgram/ml (complete inhibition) these drugs interfered with the invasion of MO4 cells from an aggregate confronting a(More)
A salt-extractable low-molecular-weight fraction has been held responsible for the resistance of cartilage to invasion by malignant cells. To test this hypothesis, we have confronted in vitro fragments from bovine articular cartilage, from bovine nasal septum, from chick embryonic tibia, or from human knee meniscus with cells from the following malignant(More)
ST/A mouse lung cells underwent apparently spontaneous malignant alteration in tissue culture. We have compared the capacity of these cells to form malignant tumours in syngeneic animals with their behaviour in vitro. ST-L1, ST-L22, and ST-L104 cells were malignant, whilst ST-L108 and ST-L109 cells were not. ST-L1 and ST-L22 cells showed(More)
An Mr 57,000 single-chain chimeric plasminogen activator, K12G0S32, consisting of a variable region fragment (Fv) derived from the fibrin fragment D-dimer-specific monoclonal antibody MA-15C5 and of a 33-kDa (amino acids Ala132 to Leu411) recombinant single-chain urokinase-type plasminogen activator (rscu-PA-33k) was studied. K12G0S32, secreted by infected(More)
An anti-invasive activity has been observed with a number of agents in confronting cultures between invasive cell populations and embryonic chick heart fragments. Cytochalasins, microtubule inhibitors and dipyridamole act via intracellular targets. Inhibition of glycosylation of proteins, low temperature and alkyl lysophospholipids alter the plasma(More)
Podophyllotoxin (PPT) and its glycosylated congeners, 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside] (VP-16-213) and 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-thenylidene-beta-D-glucopyranoside] (VM-26), were studied for their effects on the following activities of MO4 mouse fibrosarcoma cells in vitro: growth as an aggregate(More)
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