R M Merzon

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L-Glutamate application can produce three different responses in the membrane potential of the Schwann cell of the tropical squid, Sepioteuthis sepioidea, which appear to be mediated by three pharmacologically distinct classes of receptor. A class of non-NMDA-type receptors, with some similarities to metabotropic glutamate receptors, mediates the(More)
The role of the amino acid glutamate in neuronal-glial signalling is becoming increasingly recognised in both vertebrate and invertebrate nervous systems (Barres, 1989). Although the ability of glutamate to depolarize cultured astrocytes has been known for some time (Bowman and Kimelberg, 1984; Kettenmann and Schachner, 1985), there has been a debate over(More)
The glutamate uptake blocker p-chloromercuriphenylsulphonic acid (PCMS) (100 mumol l-1) does not block any of the membrane potential changes induced by the application of L-glutamate to the adaxonal Schwann cells of the giant axon of the tropical squid Sepioteuthis sepioidea. This indicates that these potential changes are not due to the activation of an(More)
Substance P produced a dose-dependent, long-lasting hyperpolarization of the membrane of the Schwann cells of the giant nerve fibre of the tropical squid. A survey of the effectiveness of a range of other naturally occurring tachykinin agonists suggested that the receptors present on the squid Schwann cell belong to the subtype SP-P or NK1, for which(More)
INTRODUCTION Massive neonatal screening for phenylketonuria (PKU) began in developed countries in 1963, and eventually disappeared as a cause of mental retardation. Yet, this is not the case in most developing countries. AIM To describe the phenotype and the genotype of PKU patients with a delayed diagnosis in order to draw attention to the importance of(More)
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