R. M. Hochmuth

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The simplest model for a neutrophil in its "passive" state views the cell as consisting of a liquid-like cytoplasmic region surrounded by a membrane. The cell surface is in a state of isotropic contraction, which causes the cell to assume a spherical shape. This contraction is characterized by the cortical tension. The cortical tension shows a weak area(More)
The thickness of intact human red cell membrane is measured by a light-microscope technique in which membrane material with a known surface area is extracted into a long, thin cylindrical strand. The radius of the strand is calculated from its known length and surface area. The minimum radius, obtained at high extraction velocities or large membrane(More)
Flunarizine is a class IV calcium channel blocker which increases oxygen delivery to hypoxic regions in solid tumours, exerting a radiosensitising effect in vivo in animal tumour models. Precisely how the drug improves oxygenation is not well understood. We hypothesised that metabolic conditions present within solid tumours reduce red blood cell (RBC)(More)
The elasticity and viscosity of the human erythrocyte membrane were measured as a function of the concentration of wheat germ agglutinin (WGA) in a suspending solution containing I mg/ml albumin, ~5 x 10 s cells/ml and between 0.0 and 0.2 /ig/ml WGA. Membrane elasticity was characterized by the elastic shear modulus, which provided a measure of the(More)
Cell surfaces are often heterogeneous with respect to the lateral distribution and mobility of membrane components. Because lateral mobility is related to membrane structure, measurement of a particular component's local diffusion coefficient within a distinct surface region provides useful information about the formation and maintenance of that region.(More)
The 2000 manuscript " Micropipette aspiration in living cells " by Robert M. Hochmuth provides an excellent review on what we can learn from the micropipette aspiration experiment. • Summarize the manuscript in no more than 150 words. • Make a table summarizing the different cell types discussed in the manuscript and list their mechanical properties. • Two(More)
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