R L Ostrander

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Two structurally related triterpenoids 1 and 2 from pink peppercorn (berries of Schinus terebinthifolius) are identified and characterized as active site-directed specific competitive inhibitors of the three classes of secreted 14 kDa phospholipase A2. The inhibitors not only protect the active site histidine from alkylation but also inhibit the action of(More)
Single-crystal x-ray diffraction methods have been used to directly observe and simultaneously determine the molecular structure of the UVA induced cis-syn photocycloaddition product in a partially photolyzed single crystal of a psoralen(pyrone ring side)-DNA(thymine) interaction model compound, 1'-(8-oxypsoralen)-8'(thym-1"yl)3',6'-dioxaoctane.
C26H41NO7, Mr = 479.61, triclinic, P1, a = 11.894 (4), b = 12.360 (2), c = 9.969 (2) A, alpha = 106.11 (2), beta = 100.68 (2), gamma = 99.02 (2) degrees, V = 1349.5 (6) A3, Z = 2, Dx = 1.180 Mg m-3, Mo K alpha, lambda = 0.71069 A, mu = 0.079 mm-1, F(000) = 520, T = 296 K, R = 0.041, wR = 0.047 for 3196 observed unique reflections. A new approach to the(More)
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