R. L. Haner

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A detailed characterization of an NMR flow probe for use in direct-injection sample analysis is presented. A 600-MHz, indirect detection NMR flow probe with a 120-microl active volume is evaluated in two configurations: first as a stand-alone small volume probe for the analysis of static, nonflowing solutions, and second as a component in an integrated(More)
The chemical crosslinking of modified nucleic acids via the Diels-Alder reaction is reported. For this purpose, 1,3-butadiene derived building blocks were incorporated into complementary oligodeoxynucleotides. Treatment of the obtained duplex with difunctional dienophiles results in the clean crosslinking of the two strands. Non-crosslinked adducts arising(More)
Antisense oligonucleotides offer a new way of treating genetically based diseases by interfering with protein expression on the mRNA level. First generation phosphorothioate antisense oligonucleotides have shown promising results in animal experiments and several compounds are currently being tested in the clinics against a variety of diseases.(More)
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