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A review of current opinion on paraneoplastic syndrome pathology is presented. It is supplemented by a reference to the author's own cases (paraneoplastic cerebellar degeneration with Purkinje cell lesion and vacuolar spongiform degeneration of the granuloneuronal layer of the cerebellar cortex).
The intracellular penetrating activity of amoebas of Limax-type (vs. Naegleria fowleri) was observed in a previously published case of the PAME with fulminant lethal course in man. This invasion concerned some ganglion cells of the cerebral cortex and - exceptionally - also the Purkinje-cells in the cerebellum. As to the formal genesis, adjacent and… (More)