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Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition.

• Alba Guarné, José R. Tormo, R Kirchweger, D M Pfistermueller, I. Fita, T. Skern
• The EMBO journal
• 1998

The leader protease of foot-and-mouth disease virus, as well as cleaving itself from the nascent viral polyprotein, disables host cell protein synthesis by specific proteolysis of a cellular protein:… (More)

Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation.

• Barry J. Lamphear, R Kirchweger, T. Skern, R. E. Rhoads
• The Journal of biological chemistry
• 1995

Cap-dependent binding of mRNA to the 40 S ribosomal subunit during translational initiation requires the association of eukaryotic initiation factor 4G (eIF4G; formerly eIF-4 gamma and p220) with… (More)

Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma.

• R Kirchweger, Emanuel Ziegler, +7 authors R. E. Rhoads
• Journal of virology
• 1994

Many picornaviruses cause a dramatic decrease in the translation of cellular mRNAs in the infected cell, without affecting the translation of their own RNA. Specific proteolysis of protein synthesis… (More)

Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin.

• Emanuel Ziegler, Andrew M Borman, R Kirchweger, T. Skern, Kathryn Kean
• Journal of virology
• 1995

Rhinovirus and enterovirus 2A proteinases stimulate translation initiation driven from the cognate internal ribosome entry segment (IRES) (S. J. Hambidge and P. Sarnow, Proc. Natl. Acad. Sci. USA… (More)

Patterns of allele losses suggest the existence of five distinct regions of LOH on chromosome 17 in breast cancer.

• R Kirchweger, Robert Zeillinger, C. Schneeberger, Paul Speiser, G. Louason, Charlles Theillet
• International journal of cancer
• 1994

Chromosome 17 is a frequent target during breast-cancer formation and progression. It has been shown to be affected by allele losses at multiple sites, as well as by DNA amplification. Our aim was to… (More)

elF4G and its proteolytic cleavage products: effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs.

• Andrew M Borman, R Kirchweger, Emanuel Ziegler, R. E. Rhoads, T. Skern, Kathryn Kean
• RNA
• 1997

Rhinovirus 2A and foot-and-mouth disease virus Lb proteinases stimulate the translation of uncapped messages and those carrying the rhinovirus and enterovirus Internal Ribosome Entry Segments… (More)

Crystallization and preliminary X-ray diffraction studies of the Lb proteinase from foot-and-mouth disease virus.

• Alba Guarné, R Kirchweger, +4 authors I. Fita
• Protein science : a publication of the Protein…
• 1996

Different crystal forms of the C23A mutant from the leader proteinase of foot-and-mouth disease virus were obtained by the hanging drop vapor diffusion technique, using MgCl2 and PEG 6000 as… (More)

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