R. Keller

R. Keist2
R. Schwartz-Albiez2
V. Schirrmacher2
2R. Keist
2R. Schwartz-Albiez
2V. Schirrmacher
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Adherent, predominantly phagocytic mononuclear cells from various rat tissues express spontaneous cytoxicity against diverse target cells in vitro. The extent to which cytotoxicity was expressed by effector cells depended on the age of donors. Cytolytic effector-cell capacity was already fully developed a few days after birth, and persisted over many(More)
FOR THE MEASUREMENT of cytolytic capacities expressed by effector cells involved in cellular immunity, a variety of cytotoxicity assays have been developed. Although the widely used isotope-release assays are generally more objective and reliable than visual assays, such tests involve numerous technical problems, especially when consistent expression of the(More)
THE phorbol diester, 12-0-tetradecanoyl-phorbol-1 3-acetate (TPA) and various other tumour promoters affect cells in culture at various levels and in a variety of ways (Slaga et al., 1978). It is now increasingly appreciated that tumour promoters can affect mononuclear phago-cytes at different levels and with opposite consequences: (1) precursors of the(More)
Even though many studies suggest that proteoglycans with their structurally determinative polysaccharide chains, the glycosaminoglycans (GAGs), are important mediators of cellular interactions, little is known about expression and possible functions of these macromolecules expressed by tumour cells during the transition from low to highly metastatic(More)
Prolonged interaction in vitro between C. parvum-induced adherent predominantly phagocytic rat peritoneal cells and syngeneic or xenogeneic tumour targets consistently produces marked cytotoxicity. In the presence of irradiated foetal liver cells, expression of cytotoxicity is blocked in a dose-dependent manner. The ability of liver cells to compete with(More)
IT IS generally agreed that ageing appears to be a strong determinant of cancer incidence (Doll et al., 1970; Teller, 1972; Peto et al., 1975). This suggests that the steps leading to malignant transformation accumulate over many years. Environmental factors are particularly determining for carcinogenesis, but the exact role played by transforming agents(More)
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