R. Keira Curtis

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The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta) has been implicated in important metabolic processes. A mouse lacking PGC-1beta (PGC1betaKO) was generated and phenotyped using physiological, molecular, and bioinformatic approaches. PGC1betaKO mice are generally viable and metabolically healthy.(More)
Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2(-/-) Lep(ob)/Lep(ob) (POKO mouse), resulted in decreased fat mass, severe insulin resistance, beta-cell failure, and dyslipidaemia. Our results indicate that the PPARg2 isoform plays an important(More)
DNA microarrays produce large amounts of data. Complex changes in gene expression are revealed; sometimes thousands of mRNAs change between experiments. Here we apply modular regulation analysis to microarray data to reveal and quantify the mRNA changes that are important for cellular responses. The mRNAs are sorted into clusters. How strongly a(More)
MOTIVATION Microarray experiments measure complex changes in the abundance of many mRNAs under different conditions. Current analysis methods cannot distinguish between direct and indirect effects on expression, or calculate the relative importance of mRNAs in effecting responses. RESULTS Application of modular regulation analysis to microarray data(More)
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1b (PGC-1b) has been implicated in important metabolic processes. A mouse lacking PGC-1b (PGC1bKO) was generated and phenotyped using physiological, molecular, and bioinformatic approaches. PGC1bKO mice are generally viable and metabolically healthy. Using systems(More)
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