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In this review article an insight has been made into the strong possibility of the role of vasopressin (VP) in the control of circadian rhythms which has emerged from the results of the recent experiments in this field. A role for VP, which is identified in the suprachiasmatic nuclei (SCN) of mammals, as a neurotransmitter/neuromodulator in the central(More)
The effect of cutaneous tactile stimulation on motoneuron excitability was studied in 20 normal subjects and in patients of hemiplegia (n = 14) and paraplegia (n = 15) by plotting H-reflex recovery curves during application of twin pulses alone ("basal" H-reflex recovery curve), and twin pulses synchronized with electrical stimuli evoking tactile sensation(More)
Effect of lithium injections through chronically implanted cannulae into the bilateral suprachiasmatic nuclei (SCN) on the circadian rhythm of food intake was investigated in the rat. It was observed that the circadian rhythm was disrupted by injections of lithium at the beginning of the light as well as the dark phase of the LD cycle. In either case the(More)
The effect of immersion of both the hands and the feet in water at 10 degrees C on lung transfer factor for carbon monoxide (Tlco) and on pulmonary capillary blood volume (Vc) was investigated in 20 normal young adult males immediately, 60 min and 120 min after the end of the cold challenge. Vc was significantly reduced immediately and the reduction was(More)
b blocker, bisoprolol, as a first-line antihypertensive in Indian patients diagnosed with essential hypertension (BRIGHT): an open-label, multicentric observational study ABSTRACT Objectives: This study was aimed to evaluate the efficacy and tolerability of bisoprolol, in Indian patients diagnosed with stage I essential hypertension as first-line drug.(More)
OBJECTIVES This study was aimed to evaluate the efficacy and tolerability of bisoprolol, in Indian patients diagnosed with stage I essential hypertension as first-line drug. DESIGN This was an open-label, phase IV, multicentric prospective study. SETTINGS 239 outpatient centres across India. PARTICIPANTS After ethical approval, patients who were(More)
There is an indication that areas of the brain other than the suprachiasmatic nuclei (SCN), the known neural circadian pacemaker, are involved in the control of circadian rhythms. The present study investigated the role of amygdala in the circadian rhythms of food and water intake. Vasopressin and its antagonist d(CH2)5Tyr(Me)AVP were injected into the(More)
To study the effect on the circadian feeding rhythm, injections of AVP and its antagonist were made into the suprachiasmatic nuclei (SCN) of rats after implanting cannulae into the bilateral SCN. Injections of arginine vasopressin (AVP) antagonist at the beginning of the light and dark phases disrupted the circadian rhythm of food intake while injections of(More)