R Kühnel

Learn More
The presence of steroid receptors (82 tumors) and aromatase activity (39 tumors) in ovarian carcinomas was correlated with patient survival. No statistically significant correlation was found between the presence or absence of estrogen receptors (ER, 56.1%), progesterone receptors (PR, 57.3%), androgen receptors (AR, 91.5%), or aromatase activity (33.3%)(More)
Cytosols of 94 untreated common epithelial ovarian cancer tissues were analysed for the presence of estrogen-, progesterone- and androgen receptors. Androgen receptors clearly predominated (90%) over and above estrogen- (55%) and progesterone receptors (52%). Further characterisation particularly of the androgen receptor revealed steroid-receptor complex(More)
All human ovarian tumors (n = 32) analysed were positive for cytokeratin except for a single case. OV-TL 3 stained 96% (26/27) and 1 out of 4 controls, while OC-125 stained 86% (24/27) and 3 out of 4 non-ovarian carcinomas. Androgen receptors predominated (AR-96%) compared to estrogen (ER-32%) or progestin (PgR-50%) receptors in the ovarian carcinomas.(More)
Androgen receptors (AR) predominated (98%) in the cytosols of human ovarian carcinomas (n = 40), compared to estrogen (ER)-45%, and progestin (PgR)-53% receptors. The average age of the patients was 58 years. Serum levels of estradiol-17 beta (E2), testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were within the normal(More)
The histologic, morphometric, immunohistochemical, and ultrastructural study of a malignant Brenner tumor in a postmenopausal women presenting with vaginal bleeding is described. A comparison with transitional cell carcinomas is made, and the use of morphometry in grading the urothelial-like epithelium in malignant Brenner tumors is suggested. High(More)
A case of a malignant Brenner tumor of a postmenopausal woman presenting with vaginal bleedings is described. Clinical and laboratory findings demonstrated estrogenic secretory function and action. The presence of aromatase activity based on in vitro tumor microsomal metabolism of androgen to estrogen is described. Tumor cytosol contained progestin and(More)
Die retrosternale Infektion des vorderen Mediastinums nach herzchirurgischem Eingriff mit Sternotomie (Poststernotomie-Mediastinitis, PSM) ist eine lebensbedrohliche Komplikation. Sie stellt ein multifaktorielles und komplexes Krankheitsbild dar, an deren Diagnostik und Therapie viele Disziplinen beteiligt sind. Da verschiedene Behandlungskonzepte(More)
One hundred eight human ovarian cancers were analyzed for estrogen (ER), progestin (PgR), and androgen (AR) receptors. The receptor levels were related to histological type and grade of the tumor. There were 103 common epithelial carcinomas subdivided into serous (36), endometrioid (36), mucinous (18), clear cell (5), malignant Brenner (3), mixed epithelial(More)
  • 1