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Studies were performed to determine the effects of neurotransmitters on arginine vasotocin (AVT) release in vitro. Rat pineal glands were incubated with 10(-8)M or 10(-6)M norepinephrine (NE), dopamine (DA), serotonin (5HT), and acetylcholine (ACH) for eight h after which the concentrations of AVT in the media were determined by radioimmunoassay. With the(More)
Studies were performed to isolate peptides displaying antigonadotropic properties from bovine pineal tissue. Inhibition of compensatory ovarian hypertrophy in adult mice was used as an index of activity to guide the purification of a bovine pineal extract in order to isolate these antigonadal peptides. Defatted bovine pineal glands were extracted with(More)
The reduction of serum luteinizing hormone (LH) and testosterone in male rats by a partially purified bovine pineal extract is reported. Defatted bovine pineal glands were extracted with acetic acid and further purified on Sephadex G-25 to yield 3 antigonadotropic fractions designated at F3, F4, and F5. Each fraction was administered to young mature male(More)
STUDY OBJECTIVE The aim was to determine the number of years that could be gained by preventing avoidable deaths. DESIGN The study arose from the concept of avoidable causes of death and life expectancy at birth. Four abbreviated life tables were computed. The first included all causes of death; the second excluded all avoidable causes of death; the third(More)
The interaction of arginine vasotocin (AVT) and norepinephrine (NE) upon pineal gland indoleamine synthesis was investigated. Rat pineal glands were incubated for 10 h in Krebs--Ringer bicarbonate plus 2 mg/ml glucose, 1 mg/ml bovine serum albumin, [14C]tryptophan, NE (10(-6) M), and log doses of AVT ranging from 100 ng to 10 microgram. Incubation media(More)