A significant impairment in understanding the biology and advancing therapeutics for Waldenstrom's macroglobulinemia (WM) has been the lack of a representative cell line and animal model. We, therefore, report on the establishment of the BCWM.1 cell line, which was derived from the long-term culture of CD19(+) selected bone marrow lymphoplasmacytic cells… (More)
Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoma characterized by bone marrow (BM) involvement of IgM secreting lymphoplasmacytic cells. The induction of unfolded protein response (UPR) genes ("physiologic" UPR) enables cells to differentiate into professional secretory cells capable of production of high amounts of endoplasmic… (More)
UNLABELLED Familial disease is common in Waldenström macroglobulinemia (WM). We examined the impact of familial disease status on treatment outcome in WM and observed that familial disease was associated with inferior outcomes. However patients with familial WM receiving a bortezomib-containing regimen showed improved treatment outcomes vs. those receiving… (More)
In this paper we will discuss the implications of using all-optical OFDM in the network, the need for synchronisation and clock recovery, and demonstrate a simple all-optical clock recovery system for such superchannels. The recovered analogue clock was used to generate a second comb synchronised to the original from the transmitter.
We report for the first time an ultra-stable optical-carrier dissemination technique for transmission over a 20 km unidirectional fibre link. The optical-linewidth of the recovered carrier matches closely that of the original carrier.
In this paper we will discuss a range of applications, pertinent to phase-modulated OFDM superchannels, for which optical signal processing can be used. We demonstrate a novel technique for clock recovery of a 53.5 Gbit/s BPSK superchannel, which uses the well-known four-wave mixing process in a SOA.
We argue that the use of nonlinear semiconductor optical amplifiers for all-optical processing of phase encoded signals offers potential benefits. To illustrate the point, we demonstrate QPSK to 8PSK conversion and decomposition of QPSK to two BPSK outputs at new wavelengths by four-wave mixing.