R J Klayton

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We examined elderly heterozygotes for alpha-antitrypsin deficiency (phenotype MZ) to determine which of several factors might be associated with the development of chronic obstructive pulmonary disease (COPD). Elderly heterozygotes who smoked had a very high incidence of COPD (70 per cent), whereas homozygotes (phenotype MM) who smoked had a significantly(More)
Nineteen consecutive patients with clinically suspected sarcoidosis underwent 67Ga-scintigraphy prior to transbronchial lung biopsy (TBLB) to determine if 67Ga uptake in lung parenchyma would increase the diagnostic yield of the biopsy procedure. Biopsies were obtained from the areas showing parenchymal uptake on the 67Ga scan in 13 of the 19 patients. In(More)
Fiberoptic bronchoscopy is employed extensively in the examination of patients with pulmonary disease. As demonstrated in this large series, the procedure can be performed safely and efficiently on an outpatient basis, with the use of only topical anesthesia. Discomfort is minimal and readily accepted by most patients. Bronchial biopsies of suspected(More)
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