R. J. H. Koopman

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The new term Becker nevus syndrome is proposed for a phenotype characterized by the presence of a particular type of organoid epithelial nevus showing hyperpigmentation, increased hairiness and hamartomatous augmentation of smooth muscle fibers, and other developmental defects such as ipsilateral hypoplasia of breast and skeletal anomalies including(More)
OBJECTIVES To evaluate the usefulness of Gram staining and culture of skin lesions in patients with acute meningococcal infections. DESIGN Retrospective study. SETTING Community hospital and intensive care unit of a teaching hospital. SUBJECTS 51 patients admitted from 1989 to 1993 with proved meningococcal infections and microbiological examination(More)
Bilateral microphthalmia with blepharophimosis, linear lesions of dermal aplasia involving the face, and microcephaly were present in a newborn girl who died at age 9 months from cardiomyopathy resulting in ventricular fibrillation. Autopsy showed an atrial septum defect, persistent gross trabeculation of the left ventricle, and an arteria lusoria. This(More)
Methylmalonic acidemia is an inborn error of metabolism leading to protein intolerance. This autosomal recessive trait [8] is caused by decreased activity of methylmalonylCoA mutase or its coenzyme adenosylcobalamin, a vitamin B~2 metabolite. Seven mutations of this enzyme or its coenzyme have been identified [3]. The incidence has been estimated to be(More)
To determine whether the polymerase chain reaction could contribute to a better diagnosis of Lyme disease, skin biopsy samples from patients suffering from erythema chronicum migrans or acrodermatitis chronica atrophicans were tested for the presence of Borrelia burgdorferi by a polymerase chain reaction assay, which was specific for European strains. The(More)