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OBJECTIVE Anti-RA33 antibodies occur in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD) and target the A2/B1 protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex 4 which forms part of the spliceosome. The aim of the present study was to evaluate the immune response and(More)
Bone marrow plasma cells constitute the bulk of malignant cells in multiple myeloma patients. B-lymphocytes having immunoglobulin heavy chain gene rearrangements identical to those of the malignant clone (clonally related B-lymphocytes) may function as malignant plasma cell precursors. We and others proposed the use of anti-idiotypic antibodies to isolate(More)
Collagen arthritis is an experimental model for rheumatoid arthritis which is induced in susceptible DBA/1 mice after immunization with native type II collagen (CII). All immunized mice exhibit a humoral response to CII regardless of the occurrence of articular pathology. In order to further analyze the determinants recognized on the CII molecule, we have(More)
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