R. Hardwin Mead

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For those who have not recognized the disparate natures of tests of statistical hypotheses and tests of scientific hypotheses, one-tailed statistical tests of null hypotheses such as ∂ ≤ 0 or ∂ ≥ 0 have often seemed a reasonable procedure. We earlier reviewed the many grounds for not regarding them as such. To have at least some power for detection of(More)
Experimental chimaeras have been used to estimate the number of tissue progenitors from the variation in the proportions of cells of each genotype that can be found in a given tissue. However, because of a failure to appreciate the importance of assessing the extent of agreement required between the predictions made by a specific mathematical model and the(More)
SUMMARY In this paper, we consider experiments for which experimenters have some prior information on the probability of effects being non-negligible in advance of collecting their data. We suggest using this prior information as a tool to help experimenters to decide the appropriate run-sizes that experimenters should use. In addition, we introduce a(More)
PURPOSE The purpose of this study was to evaluate how atrial fibrillation (AF) ablation has evolved over time with regards to patient characteristics, procedural variables, complications, and outcomes. METHODS We evaluated trends over time from 2003 to 2010 in clinical characteristics, procedural variables, complications, and Kaplan-Meier AF-free rates(More)
PURPOSE Atrial fibrillation (AF) ablation uses expensive technology and equipment. Physicians have considerable latitude over equipment choice. Average Medicare reimbursement is $10,338 for uncomplicated AF ablations. The purpose of this study is to evaluate the cost of special equipment chosen by physicians to perform AF ablation. METHODS We obtained the(More)
AIMS Atrial fibrillation ablation requires peri-procedural oral anticoagulation (OAC) to prevent thromboembolic events. There are several options for OAC. We evaluate peri-procedural AF ablation complications using a variety of peri-procedural OACs. METHODS AND RESULTS We examined peri-procedural OAC and groin, bleeding, and thromboembolic complications(More)
AIMS Atrial fibrillation (AF) ablation is generally performed after patients fail antiarrhythmic drug (AAD) therapy. Some patients have drug contraindications or choose to avoid a lifetime of drug therapy. Little is known about the impact of previous drug therapy on ablation outcomes. We evaluated AAD use before AF ablation and its impact on ablation(More)
AIMS Atrial fibrillation (AF) is associated with a high incidence of strokes/thromboembolism. The CHADS2 score assigns points for several clinical variables to identify stroke risk. The CHA2DS2-VASC score uses the same variables but also incorporates age 65 to 74, female gender, and vascular disease in an effort to provide a more refined risk of(More)
PURPOSE This study was conducted to examine the outcomes in patients with prior stroke/transient ischemic attack (CVA/TIA) after atrial fibrillation (AF) ablation and the feasibility of discontinuing oral anticoagulation (OAC). METHODS This study examined long-term outcomes following AF ablations in 108 patients with a history of prior thromboembolic(More)