R. Halford Brian

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Deciphering the contribution of genetic instability in somatic cells is critical to our understanding of many human disorders. Myotonic dystrophy type 1 (DM1) is one such disorder that is caused by the expansion of a CTG repeat that shows extremely high levels of somatic instability. This somatic instability has compromised attempts to measure(More)
The networked command and video-assisted control of unmanned ground systems (UGSs) is an operational scenario that is of increasing tactical relevance. Following a summary of the requirements that a mobile ad hoc networking architecture must meet in order to provide reliable UGS teleoperation, this paper proposes barrage relay networks (BRNs) as a potential(More)
Myotonic dystrophy type 1 (DM1) is caused by the expansion of an unstable CTG repeat (g.17294_17296(45_1000)) with more repeats associated with increased disease severity and reduced age at onset. Expanded disease-associated alleles are highly unstable in both the germline and soma. Germline instability is expansion biased, providing a molecular explanation(More)
Myotonia congenita is a muscular disease characterized by myotonia, hypertrophy, and stiffness. It is inherited as either autosomal dominant or recessive known as Thomsen and Becker diseases, respectively. Here we confirm the clinical diagnosis of a family diagnosed with a myotonic condition many years ago and report a new mutation in the CLCN1 gene. The(More)
Comments: We have confirmed the clinical diagnosis of a family diagnosed with a myotonic condition many years ago and report here, a new mutation in the CLCN1 gene. The clinical diagnosis was established using ocular, cardiac, neurological and electrophysiological tests and the molecular diagnosis was done by PCR, SSCP and sequencing of the CLCN1 gene. The(More)
Brain, R. H. F. (1973). Thorax, 28, 515-520. Surgical management of hiatal herniae and oesophageal strictures in systemic sclerosis. The clinical manifestations of 10 patients with systemic sclerosis whose oesophageal complications were managed by surgery are reported. Ninety per cent had a severe ulcerating type of oesophagitis and all had hiatal herniae(More)
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