R. H. Wilson

G. W. Johnston2
E. McIlrath1
R. J. Morrehead1
2G. W. Johnston
1E. McIlrath
1R. J. Morrehead
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Survival from colorectal cancer has not improved over the last four decades despite advances in surgery and anaesthesia. The answer to the question whether adjuvant chemotherapy and radiotherapy will improve survival from the disease can only come from randomised, controlled trails. In the future, immunotherapy and gene therapy may be of benefit but these(More)
Carcinoid tumours are rare with an annual incidence of 1.3 per 100,000 in the N. Ireland population.' Carcinoid tumours are unusual in that hepatic metastases are compatible with a 20 to 40% five year survival.2 Nevertheless, most patients become symptomatic when hepatic metastasis occurs. The resulting local symptoms and those of the carcinoid syndrome(More)
This study describes a new technique for the visualisation and quantitation of glandular epithelial cell proliferation in gastrointestinal mucosa using computerised three-dimensional reconstruction. The tissue used in this study was colorectal biopsy tissue infiltrated in vitro with bromodeoxyuridine (BrdU), although the method could be applied to any(More)
Metastasis to the odontoid peg is a rare condition. We report a case where such a metastasis from an oesophageal adenocarcinoma caused problems in both diagnosis and management. This is the first case to our knowledge to originate from a primary oesophageal adenocarcinoma. CASE REPORT. A 58 year old male was admitted with dysphagia and weight loss.(More)
INTRODUCTION Proximal malignant biliary obstruction can be cured only by surgery. Such treatment may involve hepatic resection and is associated with significant morbidity and mortality. Unfortunately up to 90% of patients with this problem are either unfit or unsuitable for a curative procedure.' Conventional surgical decom-pression for these patients with(More)
Acute cholecystitis is usually treated conservatively, and surgery performed electively. Complications of cholecystitis such as empyema and perforation may be difficult to diagnose preoperatively. Delay in diagnosis and subsequent operative intervention results in increased morbidity and mortality. Prompt recognition and management are necessary to improve(More)
Acute necrotizing pancreatitis is a severe disease with a mortality often greater than 50 per cent. Partial or total pancreatectomy in this condition is a major surgical procedure with a hospital mortality in excess of 40 per cent. Recently there has been a move towards limited resection and open drainage. We report a case which illustrates the new(More)
We have developed a FORTRAN programme for scanning DNA sequences for potential Z-DNA forming regions using the One-Sample Runs Test. The programme also detects other non-random arrangements of purines and pyrimidines on the same strand and will detect purine- or pyrimidine-rich strands and G:C- or A:T-rich regions. A series of test statistics are produced(More)
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