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Detailed data were provided by the Oxford Survey of Childhood Cancer OSCC on deaths from childhood cancer in Britain after irradiation of the fetus during diagnostic radiology of the mother. In each age group at death, 0-5, 6-9 and 10-15 years, excess cancer deaths decreased suddenly for births in and after 1958. A major factor was concerted action(More)
A re-analysis of published data from the Oxford Childhood Cancer Survey shows that the frequency of leukaemia and of solid cancers in childhood is greater following antenatal x-radiography, not only in singleton births but also in monozygotic and dizygotic twins. The radiography rate was 10% in singletons and 55% in twins. A similar excess of leukaemia and(More)
  • R H Mole
  • The British journal of radiology
  • 1993
Aspects of intrauterine development relevant to radiological protection but not considered in the recently revised Recommendations of ICRP (1991a) include (i) recently acquired evidence on the totipotency of cells of the morula with implications for dosimetry and risk in the first week of human development in utero; (ii) much older evidence on the earliest(More)
  • R H Mole
  • The British journal of radiology
  • 1979
The evidence relating to pre-natal radiation exposure and the subsequent occurrence of malformations and cancer suggests that the overall risk lies in the range 0--1 cases per 1000 irradiated by one rad in utero in the first four months of pregnancy. The natural level of occurrence of serious handicaps in average pregnancies is at least 30 times higher. Is(More)
  • R H Mole
  • The British journal of radiology
  • 1975
Cancer is naturally very common, and practical questions about the possibility of radiation-induced harm are often questions about what in other contexts would be called background noise. Central to the question of whether small radiation exposures are carcinogenic is the effect of antenatal radiography. A comparison of singleton and twin births with(More)
The form of the dose-response for induction of malignant diseases in vivo by ionizing radiation is not yet established in spite of its scientific interest and its practical importance. Considerably extended observations have confirmed that the dose-response for acute myeloid leukaemia induced in male CBA/H mice by X-ray exposure is highly curvilinear. The(More)
The 10-day option aimed at restricting all radiography of potentially fertile women to the first third of the menstrual cycle was introduced in 1959 without any valid supporting evidence. No earlier or later experimental evidence has indicated that diagnostic radiography involving the early embryo might carry a measurable risk to the individual developing(More)