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Transplantation of insulin secreting tissue as a free graft has the potential to become a safe and simple procedure to cure diabetes. However, clinical results, i.e. achievement of insulin independency, are poor, in spite of the use of immunosuppressive regimens, which are regularly successful in whole organ transplantation. In contrast to whole organ(More)
Expression of a transforming Harvey or Kirsten ras gene caused opposing effects in the ability of platelet-derived growth factor (PDGF) and bradykinin to activate phospholipase C-mediated phosphoinositide hydrolysis. In [3H]inositol-labeled rat-1 fibroblasts, PDGF (5 ng/ml) resulted in a 2-fold increase in the level of [3H]inositol trisphosphate (InsP3)(More)
Die Transplantation von isolierten Langerhans-Inseln wäre ein einfaches and sicheres Verfahren zur Behandlung des Diabetes mellitus. Die bisherigen klinischen Ergebnisse sind jedoch nicht ermutigend. Im Gegensatz zu Herz-, Leber- oder Nierentransplantaten, welche unmittelbar anastomosiert werden, ist bei der Transplantation von Langerhans-Inseln der aktive(More)
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