R Goldstein

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The present study was performed on 615 male subjects referred to the Sleep Medicine Center at Tel Hashomer, Israel, and polysomnographically recorded for a single night between January 1, 1990 and December 31, 1993. The study suggests the existence of a circannual rhythm of rapid eye movement (REM) sleep time with an acrophase during December-January and a(More)
The pineal content of arginine vasotocin in the male rat is subject to diurnal changes, having a high value around noon and a low value around midnight. Since in rats exposed to 24 h constant light the pineal content in arginine vasotocin decreases, and in the rats exposed to 24 h constant darkness the pineal content in arginine vasotocin increases, it(More)
In order to investigate the effects of myelin basic protein (MBP) on sleep parameters, adult cats received 10 micrograms of guinea pig MBP into the third ventricle of the brain and were subsequently recorded for 8 hours. In comparison with both saline solution (0.1 ml) and 10 micrograms basic proteins (protamines and histones), MBP specifically produced a(More)
The intracarotid injection of both synthetic melanocyte-stimulating hormone release-inhibiting factor (MIF) and purified MIF prepared from bovine hypothalami induces arginine vasotocin release into cerebrospinal fluid of cats and significantly decreases the pineal arginine vasotocin content at 5 minutes after the injection. The present results demonstrate(More)
Pinealectomy in immature (25-day-old) male Wistar rats significantly decreased the content of 5-hydroxytryptamine (5-HT) in the hypothalamus and increased concentrations of plasma LH and FSH 3 days after surgery. Extremely small amounts (10(-4) pg) of arginine-vasotocin (AVT) injected into the third ventricle (pineal recess) 5 min after pinealectomy(More)
The lumbar cerebrospinal fluid (CSF) collected from 6 narcoleptic patients (three males and three females) aged between 31 and 47 years, as well as from 2 patients having Pickwickian syndromes with hypersomnia attacks (two males), aged 43-51 years, contained relatively high amounts of arginine vasotocin (AVT) only if the CSF was removed after a REM sleep(More)
Active sleep, brain weight as well as total lipids and galactolipids were assayed in 8-day-old rat pups, after daily administration (between 2 and 8 days of postnatal age) of saline, arginine vasotocin (AVT) (10(-7) mg), picrotoxin (5 x 10(-5) mg), valproic acid (10(-5) and 10(-6) mg) or of AVT + picrotoxin and AVT + valproic acid. AVT increases active(More)