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The assessment of cell proliferation in colorectal tissue may provide information with both prognostic and therapeutic implications. A variety of methods are available, including flow cytometric estimations of S phase fraction, immunohistochemical and autoradiographic visualization of exogenous and endogenous proliferation proteins, and morphological and(More)
The thymidine analogue, bromodeoxyuridine, is substituted into DNA during DNA synthesis and can be used to identify those cells which have passed through the S-phase of the cell cycle. Incorporated bromodeoxyuridine can be detected using anti-bromodeoxyuridine monoclonal antibodies which bind to the exposed bromodeoxyuridine in single-stranded DNA after a(More)
The case notes of 15 patients with Krukenberg tumours were studied to determine the incidence, presentation, clinical findings and prognosis of the disease in Northern Ireland. Patients tended to be young and premenopausal. A short history of abdominal pain was the most frequent presenting complaint, abdominal swelling being second. Menstrual irregularities(More)
The use of nuclear bone scanning and liver ultrasonography to stage breast cancer is an established practice in many hospitals. A 3 year prospective study was undertaken to assess the usefulness of these two investigations. Three hundred and fifty-eight patients were analysed: 133 had stage I disease, 188 were stage II and 37 were stage III. Bone scans were(More)
This document describes the NICMOS calibration activities for Cycle 11. It complements the SMOV3b and the NICMOS Cycle 10 interim calibration programs. These activities cover a period of 13 months and pursue the following major objectives: i) to monitor the main instrument properties, ii) to test the model for generating darks, iii) to analyze in detail the(More)