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The development of diabetes mellitus has been studied in six progeny generations of female Wistar rats with alloxan diabetes coupled with normal males. An increased incidence of diabetes and its higher degree have been observed in younger generations studied. A correlation has been established between the frequency of diabetic type of glucose tolerance and(More)
The work was performed on female rats to which alloxan was administered at immature age. Placental permeability was studied in female rats, healthy ones (170 fetuses), with prediabetes (124 fetuses), with latent diabetes (102 fetuses), and with manifest diabetes (112 fetuses). Permeability of placental membrane was assessed by means of the fluorimetric(More)
The hypophysis weight significantly rises in male and female rats suffering from mild alloxan diabetes (prediabetes and the latent disease form). In pronounced diabetes, a decrease in the hypophysis weight is seen. These changes do not correlate with alterations in sex function which is essentially deranged only in pronounced diabetes mellitus when the(More)
Glycogen was determined histochemically and biochemically in the placenta of female rats with alloxan diabetes induced in sexually immature animals, including the placenta of rats treated with sulfamides before the occurrence of pregnancy. Histochemical studies were carried out on 18, and biochemical on 38 Wistar rats. Glycogen content in the mature(More)
The placenta of Wistar rats with various forms of diabetes mellitis was studied by electron microscopy. Metabolic disturbances characteristic of alloxan diabetes mellitus failed to derange the trophoblast ultrastructure during the existence of placenta and produced no changes in the ultrastructure of the fetal vessels similar to the changes in the capillary(More)
In male rats with various forms of alloxan diabetes ("prediabetes", latent and manifest diabetes) there was revealed an increase in noradrenaline level in the anterior and the medial-basal hypothalamus. A rise of dophamine content was noted in the hypothalamus of these animals. Serotonin level fell in all the parts of the hypothalamus of males with(More)
Experiments were conducted on the placentae of 18 female Wistar rats. Alloxan diabetes was induced in prepubertal rats; in some of the animals diabetes was compensated by sulphanilamides before pregnancy. Histological examination of the placentae demonstrated that prematurity signs (the presence of cytotrophoblastic and giant cells in the labyrinth) and(More)