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Pattern recognition of amino acid signals partitions the cells of the goldfish retina into nine statistically unique biochemical theme classes and permits a first-order chemical mapping of virtually all cellular space. Photoreceptors, bipolar cells, and ganglion cells display a set of unique, nominally glutamatergic type E1, E1+E2, and E4 signatures,(More)
Pattern recognition of amino acid signals partitions virtually all of the macaque retina into 16 separable biochemical theme classes, some further divisible by additional criteria. The photoreceptor-->bipolar cell-->ganglion cell pathway is composed of six separable theme classes, each possessing a characteristic glutamate signature. Neuronal aspartate and(More)
PURPOSE Expressions of certain macromolecules are altered by experimental retinal detachment in the cat. Related alterations in micromolecular signatures of neurons, Müller cells, and the retinal pigment epithelium (RPE) were investigated. METHODS High-performance immunochemical mapping, image registration, and quantitative pattern recognition were(More)
PURPOSE To establish a nomogram of amino acid signatures in normal neurons, glia, and retinal pigment epithelium (RPE) of the cat retina, guided by the premise that micromolecular signatures reflect cellular identity and metabolic integrity. The long-range objective was to provide techniques to detect subtle aberrations in cellular metabolism engendered by(More)
Treatment of Neuro2a cells with drugs known to affect the integrity of microfilaments and microtubules, as well as with a calcium ionophore produced damage to the cellular membrane that was quantifiable by measuring the release of LDH into the culture medium. Concurrent exposure of the cells to ORG 2766 was found to modulate the release of LDH in a dose-(More)
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