R F Mouradian

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The relative effectiveness of a variety of carbohydrates in preserving the structural and functional integrity of membranes at low water activities was studied, using Ca-transporting microsomes from muscle as a model membrane. The order of effectiveness (greatest to lowest) was: trehalose, lactose, maltose, cellobiose, sucrose, glucose, fructose, sorbitol,(More)
Sarcoplasmic reticulum vesicles freeze-dried in the presence of trehalose retain most of their original biological activity for short periods. When the dry vesicles are stored for longer periods in air, Ca2+-transport becomes uncoupled from ATPase activity within a few days. However, when they are stored under vacuum, ATPase activity, Ca2+ transport, and(More)
This is the first of two reports describing a National Institute for Occupational Safety and Health (NIOSH) Health Hazard Evaluation conducted in response to complaints of impotence and decreased libido among male employees who manufactured 4,4'-diaminostilbene-2,2' disulfonic acid (DAS; CAS 81-11-8), an intermediate in the manufacture of fluorescent(More)
Trehalose, and to some extent a few other carbohydrates, is capable of stabilizing the structure and function of isolated biological membranes during lyophilization. In this paper the results of investigations into the long-term stability of the lyophilized membrane-carbohydrate mixtures were reported. The effects of varying water content, oxygen level, and(More)
Gas chromatography has the potential to be a much faster method of separation than is usually realized. If column operating conditions are optimized for speed and injection band width is minimized, some simple separations can be completed in a few seconds. A prototype cryofocusing system for producing narrow injection bands with 0.25-mm i.d. columns is(More)
Gas chromatography usually is considered too slow a method to be useful for real-time or near real-time monitoring. If the chromatographic system is optimized for speed, however, it is possible to reduce retention times significantly. Recently, a fast gas chromatograph (GC) was described that allows many simple separations to be completed in 10 sec or less.(More)
Gas chromatography has the potential to be a very fast method of air monitoring in the workplace and the community. The use of "fast" gas chromatographic (GC) instrumentation and methods may allow the completion of analyses in less than 10 sec when a flame ionization detector is used and in less than 30 sec when an electron capture detector is used. In this(More)
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