R F Götte

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The resistance of Escherichia coli against the antibiotic rifampicin is caused by mutations in the rpoB gene which alter the structure of the beta subunit of the DNA-dependent RNA polymerase. By insertion-mutagenesis with bacteriophage Mu rifampicin-resistant mutants that were believed to have a sensitive RNA polymerase had been generated. For closer(More)
144 children, aged between 15 days and 12 years, suffering from febrile condition of various etiology, were treated with differentiated single doses of paracetamol (N-acetyl-p-aminophenol) in form of syrup, suppositories and a combination of syrup with the antihistamine doxylaminsuccinate. During investigation periods of four hours, applying reduced doses,(More)
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