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Phosphoinositide-specific phospholipase C (PI-PLC) activity was determined in homogenates of adipocytes treated with maximal concentrations of insulin. PI-PLC activity measured using exogenous [3H]phosphatidylinositol [( 3H]PI) and exogenous [3H]phosphatidylinositol 4,5-bisphosphate [( 3H]PIP2) was not altered by prior exposure of adipocytes to insulin. It(More)
The effects of Li(+) on phosphoinositide-specific phospholipase C activation in rat cerebral cortical slices and membranes were examined. In rat brain cortical slices labeled with [(3)H]inositol, the accumulation of labeled inositol phosphates due to carbachol was enhanced in the presence of Li(+). There was no greater effect of Li(+) in the presence of(More)
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