R Erik Holmlin

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This contribution describes an experimentally straightforward procedure for preparing and screening surfaces for their ability to resist the adsorption of proteins from solution. For brevity, we call surfaces " protein resistant " when they are resistant to the adsorption of proteins from solution. We have used this procedure to identify several functional(More)
This paper describes the use of surface plasmon resonance (SPR) spectroscopy and self-assembled monolayers (SAMs) to determine the characteristics of functional groups that give surfaces the ability to resist the nonspecific adsorption of proteins from solution. Mixed SAMs presenting different functional groups were prepared for screening using a synthetic(More)
This paper describes the use of surface plasmon resonance spectroscopy and self-assembled monolayers (SAMs) of alkanethiols on gold to evaluate the ability of surfaces terminating in different combinations of charged groups to resist the nonspecific adsorption of proteins from aqueous buffer. Mixed SAMs formed from a 1:1 combination of a thiol terminated in(More)
Understanding how electrons travel through organic matter is important in designing materials for organic microelectronics [1] and understanding biological electron-transport processes. Herein we describe a simple experimental procedure to measure rates of electron transport across organic thin films having a range of structures, compare the data for(More)
This paper describes the synthesis of bifunctional polyacrylamides containing pendant vancomycin (Van) and fluorescein groups, and the use of these polymers to direct antibodies against fluorescein to self-assembled monolayers (SAMs) presenting d-alanine-d-alanine (dAdA) groups. These polymers bind biospecifically to these SAMs via interactions between the(More)
An electrical junction formed by mechanical contact between two self-assembled monolayers (SAMs)--a SAM formed from an dialkyl disulfide with a covalently linked tetracyanoquinodimethane group that is supported by silver (or gold) and a SAM formed from an alkanethiolate SAM that is supported by mercury-rectifies current. The precursor to the SAM on silver(More)
—This paper demonstrates the use of poly(dimethyl-siloxane) (PDMS), polyurethane (PU), epoxy, and poly(methyl methacrylate) (PMMA) as mandrils to fabricate metallic heat exchangers having 300–700 m internal channels. The mandrils were prepared using two soft lithographic techniques-replica molding, and microembossing. To fabricate the heat exchangers, the(More)
Methods to generate well-defined structures composed of cells have the potential to be useful in areas where aggregates of cells are relevant: a) analytical systems that use cells as sensors; b) systems for fundamental studies of metabolism, signaling, toxicology, cellular ecology, and the biophysics of cell ± cell interactions; and c) systems that(More)
This paper describes a new type of metal-insulator-metal junction based on self-assembled monolayers (SAMs). The junction consists of a drop of liquid mercury supporting a SAM, in contact with a flat metal surface (M′), also supporting a SAM: that is, a Hg-SAM/SAM-M′ junction. This junction is stable, easy to assemble, and reproducible: it can generate(More)
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